A 5 year old female has a low-grade fever and irritability increases with movement. A 30-second seizure was noted before EMS arrival. What should you suspect?

In a case where a 5-year-old presents with a low-grade fever, irritability that worsens with movement, and a brief seizure, meningitis is a key condition to suspect. Meningitis, particularly viral or bacterial, can manifest with symptoms including fever and irritability, as the inflammation of the meninges typically causes affected individuals to experience increased sensitivity to movement or changes in position.

The presence of a seizure, even if it's brief, highlights a potential neurological compromise that could be associated with meningeal irritation. In addition, meningitis commonly presents with associated symptoms such as photophobia (sensitivity to light), neck stiffness, and altered mental status, although these may not always be overtly evident in young children who cannot express their symptoms clearly.

The other conditions have different clinical presentations and would not typically align as closely with the combination of symptoms described. For example, febrile seizures are considered in young children with fever but the irritability with movement and specific neurological signs tilt the diagnosis towards meningitis rather than purely a febrile seizure. Encephalitis would also fit some of the neurological signs, but the acute presentation with irritability and the specific context of fever suggest a more likely case of meningitis. Septic